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monocyte u937 cell lines  (ATCC)


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    ATCC monocyte u937 cell lines
    Monocyte U937 Cell Lines, supplied by ATCC, used in various techniques. Bioz Stars score: 99/100, based on 6887 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/monocytic+cell+line+u937/U-937/10__1097_slash_jom__0000000000003783-68-4-8
    Average 99 stars, based on 6887 article reviews
    monocyte u937 cell lines - by Bioz Stars, 2026-10
    99/100 stars

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    Cell Culture:

    Article Title: Differential microRNA expression profiles and predicted miRNA-mRNA regulatory networks in human macrophage-like cells infected with Leishmania infantum.
    Article Snippet: .. Briefly, the human monocytic cell line U937 (ATCC CRL-1593.2) was cultured in RPMI-1640 medium supplemented with 10% Fetal Bovine Serum (FBS), 2 mM L-glutamine, 1% penicillin/streptomycin at 37 °C and 5% CO2. ..

    Article Title: Tibetan PHD2D4E;C127S variant protects from viral diseases in hypoxia, but predispose to infections in normoxia via HIFα:IFN axis.
    Article Snippet: Isolated monocytes were seeded (0.35 × 106 cells/well) in 12-well cell plates (Corning, NY, USA), in RPMI-1640 media (Sigma Aldrich, St. Louis, USA) and supplemented with 10% (v/v) heat-inactivated fetal bovine serum (FBS; Gibco Invitrogen, USA), 1% (v/v) penicillin-streptomycin (Sigma Aldrich, USA) for 2 hrs at 37 °C in 5% CO 2 incuba- tor and used for further experiments. .. The human monocytic cell line U937 and monkey kidney cell line Vero E6 cells (all from ATCC, USA) were cultured at 37°C under 5% CO 2 and 70–80% humidity in either RPMI or DMEM (Invitrogen and Sigma Aldrich) along with 10% heat inactivated FBS and 1% (v/v) penicillin-streptomycin. ..

    Article Title: Differential microRNA expression profiles and predicted miRNA–mRNA regulatory networks in human macrophage-like cells infected with Leishmania infantum
    Article Snippet: .. Briefly, the human monocytic cell line U937 (ATCC CRL-1593.2) was cultured in RPMI-1640 medium supplemented with 10% Fetal Bovine Serum (FBS), 2 mM L-glutamine, 1% penicillin/streptomycin at 37 °C and 5% CO 2 . ..

    Article Title: Tibetan PHD2 D4E;C127S variant protects from viral diseases in hypoxia, but predispose to infections in normoxia via HIFα:IFN axis
    Article Snippet: Isolated monocytes were seeded (0.35 × 10 6 cells/well) in 12-well cell plates (Corning, NY, USA), in RPMI-1640 media (Sigma Aldrich, St. Louis, USA) and supplemented with 10% (v/v) heat-inactivated fetal bovine serum (FBS; Gibco Invitrogen, USA), 1% (v/v) penicillin-streptomycin (Sigma Aldrich, USA) for 2 hrs at 37 °C in 5% CO 2 incubator and used for further experiments. .. The human monocytic cell line U937 and monkey kidney cell line Vero E6 cells (all from ATCC, USA) were cultured at 37°C under 5% CO 2 and 70–80% humidity in either RPMI or DMEM (Invitrogen and Sigma Aldrich) along with 10% heat inactivated FBS and 1% (v/v) penicillin-streptomycin. ..

    Article Title: Differential modulation of the sGC-cGMP pathway by sGC stimulators and activators in human lung cells.
    Article Snippet: Human lung microvascular endothelial cells (HMVEC-L, CC-2527) (Lonza, Basel, Switzerland) were cultured in EBM2 endothelial growth medium (Lonza, Basel, Switzerland). .. The monocytic cell line U937 (CRL-1593.2TM, ATCC®, Manassas, VA, U.S.) was maintained in suspension in RPMI medium (Lonza, Basel, Switzerland), supplemented with 10% FBS, 100 U/ml penicillin/streptomycin, and 2.5 μg/ml amphotericin B, and chinese hamster ovary cells (CHO-K1; EP-CL-0062) (Elabscience, Houston, TX, U.S.) were cultured in F-12 K medium (Corning, New York, NY, U.S.), supplemented with 10% FBS, 100 U/ml penicillin/streptomycin, and 2.5 μg/ml amphotericin B. ..

    Suspension:

    Article Title: Differential modulation of the sGC-cGMP pathway by sGC stimulators and activators in human lung cells.
    Article Snippet: Human lung microvascular endothelial cells (HMVEC-L, CC-2527) (Lonza, Basel, Switzerland) were cultured in EBM2 endothelial growth medium (Lonza, Basel, Switzerland). .. The monocytic cell line U937 (CRL-1593.2TM, ATCC®, Manassas, VA, U.S.) was maintained in suspension in RPMI medium (Lonza, Basel, Switzerland), supplemented with 10% FBS, 100 U/ml penicillin/streptomycin, and 2.5 μg/ml amphotericin B, and chinese hamster ovary cells (CHO-K1; EP-CL-0062) (Elabscience, Houston, TX, U.S.) were cultured in F-12 K medium (Corning, New York, NY, U.S.), supplemented with 10% FBS, 100 U/ml penicillin/streptomycin, and 2.5 μg/ml amphotericin B. ..



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    PCA,principal component analysis of differentially expressed genes in PRF-activated <t>U937</t> and THP-1 macrophages. The plot depicts the sample distribution in a two-dimensional space defined by the first and second principal components of the covariance matrix. Gene expression values were normalized and expressed as logCPM, log counts per million.
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    Image Search Results


    PCA,principal component analysis of differentially expressed genes in PRF-activated U937 and THP-1 macrophages. The plot depicts the sample distribution in a two-dimensional space defined by the first and second principal components of the covariance matrix. Gene expression values were normalized and expressed as logCPM, log counts per million.

    Journal: Frontiers in Immunology

    Article Title: Transcriptomic characterization of platelet-rich fibrin-induced macrophage responses identifies U937 cells as a sensitive bioassay

    doi: 10.3389/fimmu.2026.1722342

    Figure Lengend Snippet: PCA,principal component analysis of differentially expressed genes in PRF-activated U937 and THP-1 macrophages. The plot depicts the sample distribution in a two-dimensional space defined by the first and second principal components of the covariance matrix. Gene expression values were normalized and expressed as logCPM, log counts per million.

    Article Snippet: The human monocytic cell lines U937 (CRL-1593.2) and THP-1 (TIB-202) were obtained from the American Type Culture Collection (ATCC, Manassas, VA, USA).

    Techniques: Gene Expression

    Volcano plot analysis of differentially expressed genes in U937 and THP-1 macrophages treated with PRF. Volcano plots illustrate upregulated (red) and downregulated (blue) genes in U937 and THP-1 cells following PRF exposure. The annotated data points represent the 50 genes with the greatest Euclidean (Manhattan) distance from the origin that exceed the defined significance thresholds (dashed lines). Thresholds were set at –log 10 (p) ≥ 2.0 and |log 2 fold change| ≥ 3.0.

    Journal: Frontiers in Immunology

    Article Title: Transcriptomic characterization of platelet-rich fibrin-induced macrophage responses identifies U937 cells as a sensitive bioassay

    doi: 10.3389/fimmu.2026.1722342

    Figure Lengend Snippet: Volcano plot analysis of differentially expressed genes in U937 and THP-1 macrophages treated with PRF. Volcano plots illustrate upregulated (red) and downregulated (blue) genes in U937 and THP-1 cells following PRF exposure. The annotated data points represent the 50 genes with the greatest Euclidean (Manhattan) distance from the origin that exceed the defined significance thresholds (dashed lines). Thresholds were set at –log 10 (p) ≥ 2.0 and |log 2 fold change| ≥ 3.0.

    Article Snippet: The human monocytic cell lines U937 (CRL-1593.2) and THP-1 (TIB-202) were obtained from the American Type Culture Collection (ATCC, Manassas, VA, USA).

    Techniques:

    Heatmap of differentially expressed genes in U937 and THP-1 macrophages exposed to PRF lysates. The heatmap visualizes the 395 upregulated and 372 downregulated genes in U937 cells, and the 116 upregulated and 149 downregulated genes in THP-1 cells, following exposure to PRF lysates. Differentially expressed genes were defined by an adjusted p-value < 0.05. The dataset integrates transcriptional data from three independent PRF preparations. Color gradients indicate relative expression levels, with red representing upregulation and blue representing downregulation; color intensity reflects the magnitude of the expression change.

    Journal: Frontiers in Immunology

    Article Title: Transcriptomic characterization of platelet-rich fibrin-induced macrophage responses identifies U937 cells as a sensitive bioassay

    doi: 10.3389/fimmu.2026.1722342

    Figure Lengend Snippet: Heatmap of differentially expressed genes in U937 and THP-1 macrophages exposed to PRF lysates. The heatmap visualizes the 395 upregulated and 372 downregulated genes in U937 cells, and the 116 upregulated and 149 downregulated genes in THP-1 cells, following exposure to PRF lysates. Differentially expressed genes were defined by an adjusted p-value < 0.05. The dataset integrates transcriptional data from three independent PRF preparations. Color gradients indicate relative expression levels, with red representing upregulation and blue representing downregulation; color intensity reflects the magnitude of the expression change.

    Article Snippet: The human monocytic cell lines U937 (CRL-1593.2) and THP-1 (TIB-202) were obtained from the American Type Culture Collection (ATCC, Manassas, VA, USA).

    Techniques: Expressing

    Venn analysis of differentially expressed genes in U937 and THP-1 macrophages treated with PRF lysates. Venn diagrams show the overlap of upregulated and downregulated genes between U937 and THP-1 cells after exposure to PRF lysates (adjusted p < 0.05). A total of 28 genes were commonly upregulated, and 20 genes were commonly downregulated in both cell lines.

    Journal: Frontiers in Immunology

    Article Title: Transcriptomic characterization of platelet-rich fibrin-induced macrophage responses identifies U937 cells as a sensitive bioassay

    doi: 10.3389/fimmu.2026.1722342

    Figure Lengend Snippet: Venn analysis of differentially expressed genes in U937 and THP-1 macrophages treated with PRF lysates. Venn diagrams show the overlap of upregulated and downregulated genes between U937 and THP-1 cells after exposure to PRF lysates (adjusted p < 0.05). A total of 28 genes were commonly upregulated, and 20 genes were commonly downregulated in both cell lines.

    Article Snippet: The human monocytic cell lines U937 (CRL-1593.2) and THP-1 (TIB-202) were obtained from the American Type Culture Collection (ATCC, Manassas, VA, USA).

    Techniques:

    Functional enrichment analysis of upregulated genes in U937 macrophages stimulated with PRF lysates. Functional enrichment analysis, also known as over-representation analysis (ORA), was performed using the g:Profiler web-based platform. The plot depicts the top significantly enriched pathways derived from Gene Ontology and other integrated databases. Pathways are ranked and labeled numerically according to significance. P-values were adjusted for multiple testing using the Benjamini–Hochberg correction method (Padj).

    Journal: Frontiers in Immunology

    Article Title: Transcriptomic characterization of platelet-rich fibrin-induced macrophage responses identifies U937 cells as a sensitive bioassay

    doi: 10.3389/fimmu.2026.1722342

    Figure Lengend Snippet: Functional enrichment analysis of upregulated genes in U937 macrophages stimulated with PRF lysates. Functional enrichment analysis, also known as over-representation analysis (ORA), was performed using the g:Profiler web-based platform. The plot depicts the top significantly enriched pathways derived from Gene Ontology and other integrated databases. Pathways are ranked and labeled numerically according to significance. P-values were adjusted for multiple testing using the Benjamini–Hochberg correction method (Padj).

    Article Snippet: The human monocytic cell lines U937 (CRL-1593.2) and THP-1 (TIB-202) were obtained from the American Type Culture Collection (ATCC, Manassas, VA, USA).

    Techniques: Functional Assay, Derivative Assay, Labeling

    Functional enrichment analysis of downregulated genes in U937 macrophages stimulated with PRF lysates. Functional enrichment analysis (over-representation analysis, ORA) was performed using the g:Profiler web-based platform. The figure displays the top significantly enriched pathways identified from Gene Ontology and other integrated databases, ranked and labeled numerically by significance. p-values were adjusted for multiple testing using the Benjamini–Hochberg correction method (Padj).

    Journal: Frontiers in Immunology

    Article Title: Transcriptomic characterization of platelet-rich fibrin-induced macrophage responses identifies U937 cells as a sensitive bioassay

    doi: 10.3389/fimmu.2026.1722342

    Figure Lengend Snippet: Functional enrichment analysis of downregulated genes in U937 macrophages stimulated with PRF lysates. Functional enrichment analysis (over-representation analysis, ORA) was performed using the g:Profiler web-based platform. The figure displays the top significantly enriched pathways identified from Gene Ontology and other integrated databases, ranked and labeled numerically by significance. p-values were adjusted for multiple testing using the Benjamini–Hochberg correction method (Padj).

    Article Snippet: The human monocytic cell lines U937 (CRL-1593.2) and THP-1 (TIB-202) were obtained from the American Type Culture Collection (ATCC, Manassas, VA, USA).

    Techniques: Functional Assay, Labeling

    RT–qPCR validation of selected genes in U937 macrophages stimulated with PRF lysates. U937 macrophages were exposed to PRF lysates for 48 hours before quantitative RT–PCR analysis. Data represent the median of four independent experiments and two gene panels (A, B) .

    Journal: Frontiers in Immunology

    Article Title: Transcriptomic characterization of platelet-rich fibrin-induced macrophage responses identifies U937 cells as a sensitive bioassay

    doi: 10.3389/fimmu.2026.1722342

    Figure Lengend Snippet: RT–qPCR validation of selected genes in U937 macrophages stimulated with PRF lysates. U937 macrophages were exposed to PRF lysates for 48 hours before quantitative RT–PCR analysis. Data represent the median of four independent experiments and two gene panels (A, B) .

    Article Snippet: The human monocytic cell lines U937 (CRL-1593.2) and THP-1 (TIB-202) were obtained from the American Type Culture Collection (ATCC, Manassas, VA, USA).

    Techniques: Quantitative RT-PCR, Biomarker Discovery

    RT–qPCR and ELISA analysis of inflammatory gene expression in U937 and THP-1 macrophages stimulated with PRF lysates. U937 (A, B) and THP-1 (C, D) macrophages were exposed to PRF lysates for 48 hours before quantitative RT–PCR analysis. ELISA quantified CXCL8 protein levels in the corresponding cell culture supernatants. Data represent the median of independent experiments.

    Journal: Frontiers in Immunology

    Article Title: Transcriptomic characterization of platelet-rich fibrin-induced macrophage responses identifies U937 cells as a sensitive bioassay

    doi: 10.3389/fimmu.2026.1722342

    Figure Lengend Snippet: RT–qPCR and ELISA analysis of inflammatory gene expression in U937 and THP-1 macrophages stimulated with PRF lysates. U937 (A, B) and THP-1 (C, D) macrophages were exposed to PRF lysates for 48 hours before quantitative RT–PCR analysis. ELISA quantified CXCL8 protein levels in the corresponding cell culture supernatants. Data represent the median of independent experiments.

    Article Snippet: The human monocytic cell lines U937 (CRL-1593.2) and THP-1 (TIB-202) were obtained from the American Type Culture Collection (ATCC, Manassas, VA, USA).

    Techniques: Quantitative RT-PCR, Enzyme-linked Immunosorbent Assay, Gene Expression, Cell Culture